Item 1.01                      Entry into a Material Definitive Agreement.

 On June 30, 2008, Peregrine Pharmaceuticals, Inc. (the “Registrant”) entered into a five-year contract worth up to $44.4 million to test and develop bavituximab and an equivalent fully human antibody as potential broad-spectrum treatments for viral hemorrhagic fever infections. The initial contract was awarded through the Transformational Medical Technologies Initiative (TMTI) of the U.S. Department of Defense's Defense Threat Reduction Agency (DTRA).

Under the terms of the contact, DTRA funds are available to cover testing and development efforts totaling up to $22.3 million over a 24-month base period, with $5 million appropriated immediately for the current federal fiscal year ending September 30, 2008. The remainder of the $22.3 million in funding is expected to be appropriated over the remainder of the two-year base period ending June 29, 2010. The contract can be extended by the DTRA beyond the base period to cover up to $44.4 million in funding over the five-year contract period.



(c)           Exhibits.  The following material is filed as an exhibit to this Current Report on Form 8-K:


Exhibit
Number

99.1           Press Release issued July 1, 2008


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
 
  PEREGRINE PHARMACEUTICALS, INC.  
       
Date: July 2, 2008
By:
/s/ Paul J. Lytle  
    Paul J. Lytle  
    Chief Financial Officer  
       



EXHIBIT INDEX

Exhibit
Number                                Description                                                                                     

99.1                      Press Release issued July 1, 2008