Item  8.01 Other Events.

On December 10, 2007, Targacept, Inc. issued a press release announcing its initiation of a Phase I clinical trial of its product candidate TC-6499, which triggers a $6.0 million milestone payment to Targacept under the terms of its alliance agreement with GlaxoSmithKline. The full text of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K.

 

Item 9.01 Financial Statements and Exhibits.

 

  (d) Exhibits

 

Exhibit
Number

  

Description

99.1

   Press release dated December 10, 2007

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

    TARGACEPT, INC.
Date: December 10, 2007  

/s/ Alan A. Musso

  Alan A. Musso
  Vice President, Chief Financial Officer and Treasurer

EXHIBIT INDEX

 

Exhibit
Number

  

Description

99.1

   Press release dated December 10, 2007