On March 24 2008, Meghan Fitzgerald, the Vice President and Chief Business Officer of Vion Pharmaceuticals, Inc. (the Company), advised the Company of her intent to resign effective April 4, 2008.
On March 28, 2008, Dr. Stephen K. Carter, a director of the Company since April 26, 2001, informed the Company that he would not stand for reelection at the Companys 2008 Annual Meeting of Stockholders. Dr. Carters decision not to stand for reelection was reached for personal reasons and was not the result of any disagreement with the Company on any matter related to its operations, policies or practices. Dr. Carter will continue to serve as a director through the date of the Companys 2008 Annual Meeting of Stockholders.
SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. VION PHARMACEUTICALS, INC. By: Name: Howard B. Johnson Title: President and Chief Financial Officer
Date: March 28, 2008
/s/ Howard B. Johnson


