| Cash Flow for Kosan Biosciences Inc. (KOSN) | | | | | | | Cash Flow | in Thousands of Dollars | | | 12/2007 | 12/2006 | 12/2005 | 12/2004 | 12/2003 | | | Net Income | (28,658) | (29,469) | (29,637) | (22,126) | (9,668) | | Depreciation & Amortization | 2,246 | 2,326 | 2,532 | 2,493 | 2,308 | | Deferred Income Taxes | - | - | - | - | - | | Operating Losses | (27) | - | 355 | 605 | 619 | | Extraordinary Losses | - | - | - | - | - | | | Decrease in Receivables | (149) | 2,167 | 711 | 4,992 | (5,148) | | Decrease in Inventories | - | - | - | - | - | | Decrease in Other Current Assets | - | - | 55 | 103 | 162 | | Increase in Payables | 5,305 | (1,445) | 1,301 | (525) | 2,852 | | Increase in Other Current Liabilities | - | - | (3,277) | (5,429) | 9,088 | | Decrease in Other Working Capital | (16,323) | 7,497 | - | - | - | | Other Non-Cash Items | 3,191 | 2,465 | - | - | - | | Net Cash from Continuing Operations | (34,717) | (16,398) | (27,282) | (18,186) | 1,884 | | Net Cash from Discontinued Operations | - | - | - | - | - | | Cash from Operating Activities | (34,717) | (16,398) | (27,282) | (18,186) | 1,884 | | | | Sale of Property, Plant, Equipment | 110 | - | - | - | - | | Sale of Short Term Investments | 69,236 | 47,350 | 61,126 | 74,983 | 99,091 | | | Purchase of Property, Plant, Equipment | (1,839) | (1,066) | (1,434) | (2,335) | (4,257) | | Acquisitions | - | - | - | - | - | | Purchase of Short Term Investments | (64,103) | (39,004) | (28,287) | (72,905) | (116,034) | | Other Investment Changes, Net | - | - | - | - | - | | Cash from Investing Activities | 3,404 | 7,280 | 31,405 | (257) | (21,200) | | | Issuance of Debt | 678 | 458 | 2,005 | 1,290 | 3,916 | | Issuance of Capital Stock | 43,253 | 27,474 | 993 | 1,502 | 26,793 | | | Repayment of Debt | (1,323) | (1,909) | (2,148) | (2,063) | (2,093) | | Repurchase of Capital Stock | - | - | - | - | - | | Payment of Cash Dividends | - | - | - | - | - | | Other Financing Charges, Net | - | - | - | - | - | | Cash from Financing Activities | 42,608 | 26,023 | 850 | 729 | 28,616 | | | | Effect of Exchange Rate Changes | - | - | - | - | - | | Net Change in Cash | 11,295 | 16,905 | 4,973 | (17,714) | 9,300 | | | Cash at Beginning of Year | 35,655 | 18,750 | 13,777 | 31,491 | 22,191 | | Cash at End of Period | 46,950 | 35,655 | 18,750 | 13,777 | 31,491 | | | |